Melo obtained his law degree from the Manuel L. Quezon University in 1956. During the 1970s, he worked for the Office of the Solicitor General. In 1986, he was appointed to the Philippine Court of Appeals by President Corazon Aquino.
Melo was appointed by President Fidel Ramos to the Supreme Court on August 10, 1992. Melo served for ten years on the High Court, retiring after reaching the mandatory retirement age of 70 on May 30, 2002.